Nationality: International Students
Application deadlines: Open
The research is supported by an ERC starting grant for 5 years (the most prestigious grant all over Europe). The main focus of the group is to develop and use state-of-the-art technologies to study the non-coding regulatory part of the genome, especially the silencers, so as to define the essential genomic elements for cell survival, development, drug response,and other important biological pathways. We have developed a unique high-throughput system to study the silencer regions of the genome (Nature Genetics. 52, 254–263, 2020；Nature Reviews Molecular Cell Biology. 2022 Nov 7). In addition, we have also developed another unique screening system using CRISPR/Cas9 to study the function of other non-coding regulatory regions. The candidate will be actively involved in these related projects. The main techniques consist of designing custom screen libraries, performing high-throughput screening, ChIP-seq, RNA-seq, CRISPR/Cas9 genome editing, cell imaging, human stem cell differentiation assays, and bioinformatics analyses, depending on the research focus of the postdoc fellow. LUMC provides an active scientific environment for training and there will be close collaborations with other groups at LUMC and worldwide.
The LUMC is the Faculty of Medicine of Leiden University, and is a center for medical innovation that aims to improve patient care through leading international research. It is ranked 34th worldwide in healthcare. The independent research group is led by Dr. Baoxu Pang, Principle Investigator/Assistant Professor, and funded by grants from Leiden University Medical Center (LUMC), Dutch Cancer Society (KWF), Health Holland (PPP-match) and the European Research Council (ERC). The Department of Cell and Chemical Biology consists of multidisciplinary research groups, and offers a stimulating and friendly working environment, with regular seminars and inter-group meetings.
The silencer regions of the genome
The successful candidate should be fluent in English,self-motivated, collaborative, with good publication records in molecular biology, cell biology, or genetics. The candidate should have a strong background in molecular biology, cell biology, and genetics (e.g. cell culture, cloning, CRISPR-Cas9 editing).
Interested candidates should submit their curriculum vitae, a short statement describing your qualifications for this position and contact information of three references, together with any questions via e-mail to: [email protected]